| 盐酸恩丹西酮包芯缓释片的研制 |
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| 引用本文： | 张宇红,黄桂华,于艳玲,韩景宾,于萍. 盐酸恩丹西酮包芯缓释片的研制[J]. 齐鲁药事, 2004, 23(8): 38-40 |
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| 作者姓名： | 张宇红 黄桂华 于艳玲 韩景宾 于萍 |
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| 作者单位： | 1. 山东大学药学院,济南,250012
2. 齐鲁制药有限公司研发部,济南,250100 |
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| 摘 要： | 目的 研制盐酸恩丹西酮包芯缓释片。方法 采用HPMC为骨质材料,通过正交设计试验优选最佳处方和工艺,考察释放介质pH值对缓释片释药特性的影响。结果及结论 释放介质pH值对盐酸恩丹西酮包芯缓释片释药影响较大,在酸性介质及中性蒸馏水中 2 4h释药完全(≥ 95 %),在 pH6 8磷酸盐缓冲液中释药不完全( <4 5 % ),0～ 14h体外释放符合零级动力学过程。
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| 关 键 词： | 盐酸恩丹西酮 缓释片 羟丙甲纤维素 释药动力学 |
| 文章编号： | 1672-7738(2004)08-0038-03 |
Preparation of dry-coated sustained-release Ondansetron hydrochloride Tablets |
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| Zhang Yu-hong,Huang Gui-hua,Yu Yan-ling,Han Jing-bin,Yu Ping. Preparation of dry-coated sustained-release Ondansetron hydrochloride Tablets[J]. qilu pharmaceutical affairs, 2004, 23(8): 38-40 |
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| Authors: | Zhang Yu-hong Huang Gui-hua Yu Yan-ling Han Jing-bin Yu Ping |
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| Affiliation: | Zhang Yu-hong,Huang Gui-hua,Yu Yan-ling1,Han Jing-bin1,Yu Ping1 |
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| Abstract: | Abstract To prepare the dry-coated sustained-release Ondansetron hydrochloride Tablets.Methods HPMC was used as the matrix material.The best formulation and preparation methods were screened out according to orthogonal experiment design method.The pH of the dissolving solution on the release behavior of sustained-release tablets was observed.Results and Conlusion The sustained-release Ondansetron hydrochloride Tablets were affected by the pH of dissolution media significantly.The drug could be sustained released completely(≥95%)at 24h in acid media and neutral distilled water.However it could not be released completely(<45%)in pH6.8 phosphate buffer.The drug release behavior of 0～14h conformed to zero-order kinetics. |
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| Keywords: | Ondansetron hydrochloride sustained-release tablets Hydroxypropylmethylcellose drug-release kinetics |
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