| ICAM-1、VCAM-1在脑缺血损伤炎症机制中的作用及调控 |
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| 引用本文： | 张丽慧,魏尔清. ICAM-1、VCAM-1在脑缺血损伤炎症机制中的作用及调控[J]. 中国药理学通报, 2005, 21(11): 1281-1285 |
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| 作者姓名： | 张丽慧 魏尔清 |
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| 作者单位： | 1. 杭州师范学院医学院药理学教研室,浙江,杭州,310018
2. 浙江大学医学院药理学教研室,浙江,杭州,310031 |
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| 基金项目： | 中国科学院资助项目，浙江省教育科研项目 |
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| 摘 要： | 细胞间黏附分子-1(ICAM-1)和血管细胞黏附分子-1(VCAM-1)在脑缺血损伤炎症过程中起着重要作用。脑缺血后ICAM-1和VCAM-1表达增加;ICAM-1、VCAM-1介导循环中的白细胞与内皮细胞黏附,进而浸润到血管外脑实质,导致缺血后炎症;抑制ICAM-1、VCAM-1表达及作用可减轻脑缺血损伤。
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| 关 键 词： | 脑缺血 细胞间黏附分子-1 血管细胞黏附分子-1 |
| 文章编号： | 1001-1978（2005）11-1281-05 |
| 收稿时间： | 2005-07-18 |
| 修稿时间： | 2005-08-19 |
Effect and modulation of ICAM-1 and VCAM-1 in the inflammatory mechanisms following cerebral ischemia |
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| ZHANG Li-hui,WEI Er-qing. Effect and modulation of ICAM-1 and VCAM-1 in the inflammatory mechanisms following cerebral ischemia[J]. Chinese Pharmacological Bulletin, 2005, 21(11): 1281-1285 |
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| Authors: | ZHANG Li-hui WEI Er-qing |
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| Affiliation: | 1. Dept of Pharmacologr Yledical School, Hangzhou Normal College, Hangzhou 310018, China ; 2. Dept of Pharmacology, School of Medicine, Zhefiang Universio, Hangzhou 310031, China |
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| Abstract: | Intercellular adhesion molecules 1(ICAM-1) and vascular cell adhesion molecule 1(VCAM-1) play important roles in the inflammatory process of cerebral ischemic injury.The expression of ICAM-1 and VCAM-1 increases following cerebral ischemia;ICAM-1 and VCAM-1 promote ischemic inflammation through mediating leukocytes adhesion to the endothelial cells and eventually migration into brain tissue;the inhibition of the overexpression and effect of ICAM-1 and VCAM-1 can reduce cerebral ischemic injury. |
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| Keywords: | brain ischemia intercellular adhesionmolecules-1 vascular cell adhesion molecule-1 |
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