Low burden of a JAK2-V617F mutated clone in monoclonal haematopoiesis in a Japanese woman with Budd-Chiari syndrome |
| |
Authors: | Kohtaro Toyama Masamitsu Karasawa Arito Yamane Hiromi Koiso Akihiko Yokohama Hideki Uchiumi Takayuki Saitoh Hiroshi Handa Ken Sato Hitoshi Takagi Shuichi Miyawaki Hirokazu Murakami Yoshihisa Nojima Norifumi Tsukamoto |
| |
Affiliation: | (1) Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan;(2) Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma, Japan;(3) Division of Internal Medicine, Saiseikai Maebashi Hospital, Gunma, Japan |
| |
Abstract: | Approximately one-half of the cases of Budd-Chiari syndrome (BCS) are caused by bcr/abl negative chronic myeloproliferative disorders (CMPDs). Furthermore, a mutation in the Janus kinase protein (JAK2-V617F) is detected in half of the patients with BCS. However, whether the JAK2 mutation is the primary event leading to CMPDs and BCS is controversial. We present a report concerning a young woman who suffered from BCS prior to the onset of CMPDs. Analysis of X-chromosome inactivation patterns in this patient, using the human androgen receptor gene demonstrated monoclonal haematopoiesis in her granulocytes. In contrast, she had a low burden of a JAK2-V617F mutation positive clone among granulocyte populations. These results suggest that the JAK2-V617F mutation occurs after the onset of monoclonal haematopoiesis; thus the V617F mutation of JAK2 may not be the primary event in the induction of BCS. |
| |
Keywords: | Chronic myeloproliferative disorder Budd-Chiari syndrome Clonality analysis JAK2-V617F Endogenous erythroid colony |
本文献已被 SpringerLink 等数据库收录! |
|