| 加味金匮肾气丸对糖尿病大鼠脑海马CA_1区神经营养因子-3表达的影响 |
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| 引用本文： | 石镇东,毛军民,张尊祥,任天荣.加味金匮肾气丸对糖尿病大鼠脑海马CA_1区神经营养因子-3表达的影响[J].河北中西医结合杂志,2011(35):4475-4476,4480. |
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| 作者姓名： | 石镇东 毛军民 张尊祥 任天荣 |
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| 作者单位： | [1]南京军区杭州疗养院,浙江杭州310007 [2]浙江中医药大学,浙江杭州310053 |
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| 基金项目： | 浙江省中医药管理局课题（2006C004） |
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| 摘 要： | 目的探讨加味金匮肾气丸对糖尿病大鼠脑海马CA1区神经营养因子3（NT-3）表达的影响。方法腹腔内注射链脲佐菌素（STZ）制作糖尿病大鼠模型,造模后以免疫组化法观察加味金匮肾气丸对大鼠脑海马CA1区NT-3表达的影响。结果加味金匮肾气丸治疗组比糖尿病组大鼠脑海马CA1区NT-3表达增加。结论加味金匮肾气丸可以有效防治糖尿病大鼠脑海马CA1区神经元退行性变化。
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| 关 键 词： | 金匮肾气丸 糖尿病 神经营养因子3 免疫组化 |
Influence of modified Jinkuishenqiwan on expression of neurotrophin-3 in brain hippocampus CA_1 area of diabetic rat |
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| Authors: | Shi Zhendong Mao Junmin Zhang Zunxiang Ren Tianrong |
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| Institution: | 1.Hangzhou Sanatorium of Nanjing Army Area,Hangzhou 310007,Zhejiang,China;2.Zhejiang Traditional Chinese Medical University,Hangzhou 310053,Zhejiang,China) |
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| Abstract: | Objective It is to approach the influence of modified Jinkuishenqiwan on the expression of neurotrophin-3（NT-3） in brain hippocampus CA1 area of diabetic rat.Methods The diabetic rat models were induced with intraperitoneal injection of streptozotocin（STZ）.After models established,the influence of modified Jinkuishenqiwan on the expression of NT-3 in brain hippocampus CA1 area of rat was observed with immunohistochemisty method.Results The expression of NT-3 in brain hippocampus CA1 area of rat in modified Jinkuishenqiwan treatment group was increased compared with that in diabetes group.Conclusion Modified Jinkuishenqiwan can effectively prevent and cure the anaplasia of neurons in brain hippocampus CA1 area of diabetic rat. |
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| Keywords: | Jinkuishenqiwan diabetes neurotrophin-3 immunohistochemistry |
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