Peptide ligands for the melanin-concentrating hormone (MCH) receptor 1 |
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Authors: | Bednarek Maria A |
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Institution: | Merck Research Laboratories, Department of Medicinal Chemistry, Rahway, NJ 07065, USA. maria_bednarek@merck.com |
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Abstract: | The melanin-concentrating hormone receptor 1 (MCH-1R) has been recognized as a receptor which mediates effects of the endogenous melanin-concentrating hormone (MCH) on appetite and body weight gain in rodents. In the last several years, a number of hMCH analogs have been designed which were potent and selective ligands for hMCH-1R. These peptidic agonists and antagonists have served as research tools in animal studies that showed a key role of the MCH-1R in the development of obesity and proved that MCH-1R antagonism can produce anti-obesity effects in rodents. |
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