Quantitative evaluation of the systemic arterial bed by parameter estimation of a simple model |
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Authors: | B Deswysen A A Charlier M Gevers |
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Institution: | (1) Department of Physiology and Department of Automatic Control and System Analysis, University of Louvain, Bruxelles and Louvain-la-Neuve, Belgium |
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Abstract: | The parameters of a simple model (r-L-C-R) of the systemic circulation are estimated from aortic root pressure and flow, which
are either simulated by a complex model of the systemic circulation or measured in dogs. This model contains one additional
parameter (inductance L) as compared with the r-C-R model proposed by Westerhof; it allows for a better representation of
the input impedance of the complex model and of the systemic circulation in dog, resulting in meaningful values for the parameters
r, C, R. Because there is a good relation between C and the sum of the compliances of the complex model, and because C varies
in the direction of the expected changes in compliance following angiotensin and sodium nitroprusside administration in dogs,
C appears to be a valid estimate of the total systemic arterial compliance. The good relation between r and the characteristic
impedance in the complex model or in the upper thoracic aorta of the dog indicates that r is a good measure of the characteristic
impedance. The r-L-C-R model therefore appears to provide a better characterisation of the left ventricular afterload than
the r-C-R model. The identification of this r-L-C-R model also permits a more convenient quantification of the afterload than
the classical computation of input impedance. |
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Keywords: | Simple model-parameter estimation Systemic arterial bed |
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