地尔硫联合硝苯地平治疗肾移植并发高血压20例

目的：研究地尔硫、硝苯地平联合用于环孢素治疗肾移植并发高血压的长期疗效。方法：将40例经环孢素治疗的肾移植并发高血压患者随机分为治疗组和对照组各20例，治疗组给予地尔硫，每次30 mg，po，bid；硝苯地平每次10 mg，po，tid。对照组只给予硝苯地平，用法同治疗组。根据血压控制情况，调整治疗组地尔硫和对照组硝苯地平剂量。对患者进行＞2 a的临床观察，观察患者血药浓度及动脉血压、肾功能。结果：地尔硫干扰环孢素代谢，导致环孢素剂量降低40.0%，但未见其增强环孢素肾毒性。两组的平均血压水平相似，维持在正常范围内。两组肾功能差异无显著性(P＞0.05)。结论：地尔硫、硝苯地平联用于肾移植并发高血压症，安全有效，并能节约肾移植患者的费用。

Diltiazem Combined with Nifedipine in Treatment of Twenty Patients with Kidney-Transplanted Hypertension

Objective:To study the therapeutic effect of diltiazem with nifedipine after kidney-transplantation with ciclosporin(CsA). Methods:Fourty patients were randomly divided into 2 group evenly. The treatment group took diltiazem 30 mg, po, bid, and nifedipine 10mg, po, tid. The control group received nifedipine 10 mg, po, tid. The drug dosages were adjusted according to the level of blood pressure. The artery pressure and renal function were checked for more than 2 years. Results:Diltiazem changed the metabolism of CsA, resulting in a forty percent reduction in CsA dose. But the risk of CsA toxicity did not increase. Conclusion:Diltiazem with nifedipine can safely be used in the treatment of hypertension after kidney transplantation, and can lower the dose of CsA.