蔗糖铁注射液联合红细胞生成素治疗肾性贫血的临床观察

目的 观察蔗糖铁注射液联合红细胞生成素治疗伴有缺铁的维持性血液透析肾性贫血患者疗效及安全性.方法 选取尿毒症维持性血液透析患者46例,按随机数字表法分为治疗组(26例)和对照组(20例).治疗组采用静脉滴注蔗糖铁100 mg,每周2次,总量达1000 mg改为100 mg,每周1次;对照组采用口服乳酸亚铁0.2 g,每日3次.红细胞生成素的使用剂量和方法两组相同,总疗程均为10周.结果 经治疗后治疗组患者血红蛋白、红细胞压积、血清铁蛋白水平与对照组比较差异有统计学意义(P<0.05).结论 蔗糖铁联合红细胞生成素治疗肾性贫血疗效优于口服铁剂联合红细胞生成素治疗.不良反应发生率更低,可作为肾性贫血患者长期补铁的方法之一.

Intravenous iron sucrose combined with erythropoiesis in the treatment of renal anemia

Objective To investigate the efficacy and security of iron sucrose combined with eryth-ropoietin on renal anemia. Methods Forty -six cases of uremia patients undergoing maintenance hemodialys-is were randomly divided into two groups:the treatment group and the control group.The patients of treatment group (n = 26) used intravenous iron sucrose 100 mg , twice a week, after a total amount of 1000 mg, then 100 mg, once Ⅰ week. The patients of control group (n = 20) took orally ferrous lactate 0.2 g , 3 times per day for 10 weeks. Erythropoietin dose was the same in both groups.Results Hemoglobin and hematocrit were significantly higher and serum ferritin significant increased in the treatment group than those in the control group (P < 0.05). Conclusion Clinical observation on the efficiency of intravenous sucrofer combined with erythropoietin in the treatment of renal anemia is effective than conventional oral iron combined with erythropoietin.