突发性耳聋患者血浆同型半胱氨酸及血液流变学指标的变化及意义

目的 探讨突发性耳聋患者血浆同型半胱氨酸（Hcy）水平的变化及其与血液流变学指标的关系。方法 选择笔者医院收治突发性耳聋患者118例,其中轻度36例,中度49例,中重度33例,同时选择健康体检者50例,分别检测血浆Hcy水平及血液流变学指标。结果 与对照组、轻度组比较,中度、中重度组血浆Hcy水平、阳性率均显著升高（P＜0.05）;随着听力损伤程度的加重,血浆Hcy水平也随之升高（P＜0.05）;与对照组比较,突发性耳聋患者各血液流变学指标均有不同程度升高,且全血黏度（低切）、血细胞比容及血小板聚集率均显著升高（P＜0.05）;突发性耳聋各组血浆Hcy与全血黏度（高切、低切）、血浆黏度、血细胞比容及血小板聚集率均呈正相关（P＜0.05）。结论 突发性耳聋患者血浆Hcy呈高表达状态,血液黏度增高,且血浆Hcy的表达与血液流变学指标密切相关。

Change and Its Significance of Plasma Homocysteine and Blood Rheology in Patients with Sudden Sensorineural Hearing Loss

Objective To explore the change of plasma homocysteine（Hcy） and its relationship with blood rheology in patients with sudden sensorineural hearing loss（SSHL）.Methods Plasma Hcy and indicators of blood rheology were detected in the patients （n =118） of mild group（n=36）,moderate group （n=49）,moderate-severe group（n =33） and normal controls（n =50）.Results The levels of plasma Hcy and positive rates in moderate group,moderate-severe group were significantly higher than those in control group and mild group （P ＜ 0.05）.With the increase of hearing loss,the level of plasma Hcy increased （P ＜ 0.05）.Compared with control group,the indicators of blood rheology was significantly increased,so were the blood viscosity （low）,hematokrit and platelet aggregation rate （P ＜ 0.05）.The level of plasma Hcy in SSHL patients was significantly positively related with blood viscosity （low,high）,plasma viscosity,hematokrit and platelet aggregation rate （P ＜ 0.05）.Conclusion Patients with SSHL have higher expression of plasma Hcy and increase of blood viscosity.plasma Hcy is positive related with indicators of blood rheology.