DOF方案一线治疗晚期胃癌的疗效观察

目的 评价DOF方案一线治疗晚期胃癌患者的有效性与安全性。方法 收集笔者所在科室2010年1月～2012年12月收治的51例初治晚期胃癌患者,在一线治疗中选用DOF方案化疗。多西他赛75mg/m2,第1天,奥沙利铂135mg/m2,第1天,氟尿嘧啶2400mg/m^2,用化疗泵持续点滴46h,亚叶酸钙200mg/m^2,第1～3天,每21天重复。化疗2～3个周期后影像学检查评价疗效,每周期评价不良反应。结果 化疗总有效率为41.2％,其中完全缓解组0例,部分缓解组21例（41.2％）,病情稳定组19例（37.2％）,疾病进展组11例（21.6％）。中位无进展生存期为5.2个月,主要不良反应为胃肠道反应及骨髓抑制。结论 DOF方案用于治疗晚期初治胃癌疗效确切,耐受性好。

Clinical Observation of DOF Regimen in Treatment of Advanced Gastric Cancer as First Line Chemotherapy

Objective To investigate the efficacy and safety of docetaxel and oxaliplatin plus fluorouracil（DOF） against advanced gastric cancer patients.Methods Fifty-one advanced or metastatic gastric cancer patients were treated by docetaxel 75mg/m^2 （day 1） and oxaliplatin 135mg/m^2 （day 1） plus fluorouracil 2400mg/m^2 （Ⅳ over 46h）,Leucovorin 200mg/m2 （day 1 to 3） every 2-3 weeks from January 2010 to December 2012.Response evaluation was performed every three cycles and toxicity was observed every cycle.Results The response rate was 41.2%.No complete response（CR） was seen,and partial response（PR） was seen in 21 patients（41.2%）.Stable disease （SD） was seen in 19 patients（37.2%）.Progressive desease （PD） was seen in 11 patients（21.6%）.The median progressive free survival was 5.2 months.The most frequent adverse reaction were bone marrow depression and gastrointestinal tract reaction.Conclusion The DOF regimen is an effective,safe and well-tolerated regimen for patients with advanced gastric cancer who have not previously received chemotherapy.