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Induction of the ceruloplasmin mRNA in Balb/C 3T3 cells after Rous-Sarcoma virus transfection
Authors:S P Kunapuli  A Kumar
Institution:1. School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan;2. PhD. Program in School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan;3. Genomics Research Center, Academia Sinica, Taipei, Taiwan;4. School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan;5. Division of Pulmonary Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan;6. Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan;7. Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;9. Department of Internal Medicine, E-Da Cancer Hospital, Kaohsiung, Taiwan;10. Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA;11. Taipei First Girl High School, Taipei, Taiwan;12. Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan;13. PhD. Program of Translational Medicine, Taipei Medical University, Taipei, Taiwan
Abstract:Ceruloplasmin is a copper containing serum glycoprotein. It is an acute-phase protein and its levels are increased in inflammation and in a number of experimental and human tumors. It is normally synthesized in the liver and not in fibroblasts. In this paper we present evidence that ceruloplasmin mRNA is synthesized in Balb/C 3T3 cells and its levels are increased about 3-fold in Rous-Sarcoma virus (RSV) transformed cells. The ceruloplasmin mRNAs from rat liver and RSV 3T3 cells have the same electrophoretic mobility.
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