| 急性髓系白血病M_2微小残留病与细胞遗传学关系探讨 |
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| 引用本文： | 陈黎,朱明清,耿美菊,王爱清,潘金兰,阮长耿.急性髓系白血病M_2微小残留病与细胞遗传学关系探讨[J].中国血液流变学杂志,2008,18(4). |
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| 作者姓名： | 陈黎 朱明清 耿美菊 王爱清 潘金兰 阮长耿 |
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| 作者单位： | 1. 苏州大学附属第一医院,江苏省血液研究所,卫生部血栓与止血重点实验室,江苏,苏州,215006
2. 苏州大学基础医学与生物科学学院,江苏苏州,215123 |
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| 摘 要： | 目的 了解急性髓系白血病(AML)M2微小残留病(MRD)水平与细胞遗传学分组的关系.方法 采用多参数流式细胞仪(MFC)进行白血病免疫分型,然后再根据白血病相关免疫表型(LAIP)选择抗体组合,完成对117例M2病人的MRD监测.结果 将初次缓解AML-M2病人的微小残留病灶水平以5×10-4为界,在细胞遗传学预后较好组、预后中等组、预后较差组之间进行比较,发现三组MRD水平差异无显著性.动态监测中比较了45例患者1年内不同遗传学分组MRD从10-3水平后上升到10-2水平的发生率:预后较好组33%,预后中等组32%,预后较差组50%.结论 MFC检测AML-M2病人MRD水平可用于评估治疗反应及预测复发.
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| 关 键 词： | 急性髓系白血病 微小残留病 流式细胞术 免疫表型 |
The Relationship of Minimal Residual Disease and Cytogenetic Characteristics in Adult Acute Myeloid Leukemia M_2 |
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| CHEN Li,ZHU Ming-qing,GENG Mei-ju,et al.The Relationship of Minimal Residual Disease and Cytogenetic Characteristics in Adult Acute Myeloid Leukemia M_2[J].Chinese Journal of Hemorheology,2008,18(4). |
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| Authors: | CHEN Li ZHU Ming-qing GENG Mei-ju |
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| Institution: | CHEN Li,ZHU Ming-qing,GENG Mei-ju,et al(The First Affiliated Hospital of Soochow University,Jiangsu Institute of Hematology,Key Laboratory of Thrombosis , Hemostasis Ministry of Health,Suzhou 215006) |
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| Abstract: | Objective To find out the relationship of minimal residual disease(MRD)and cytogenetic characteristics in adult acute myeloid leukemia(AML) M2.Methods Immunophenotyping and the level of MRD using leukemia-associated immunophenotypic(LAIP)was analysed by multiparametric flow cytometry(MFC)in 117 adult M2-AML.Results Based on cytogenetic characteristics,3 different prognostic categories were identified.The level of MRD has no difference in 3 different prognostic categories.The good prognosis,intermediate prog... |
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| Keywords: | Acute myeloid leukemia Minimal residual disease Flow cytometry Immunophenotyping |
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