Gossypin-induced analgesia in mice |
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| Authors: | S Viswanathan P T Sambantham K Reddy L Kameswaran |
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| Affiliation: | 1. Medicinal Chemistry Research Centre, Institute of Pharmacology, Madras Medical College, Madras 600 003, India |
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| Abstract: | A flavonoid, gossypin, was evaluated for its analgesic action by using acetic acid-induced writhing in mice and was compared with morphine. Gossypin inhibited writhing in a dose-dependent manner. This action was antagonised by naloxone. The pA2 values for morphine-naloxone and gossypin-naloxone were almost identical suggesting a definite involvement of opiate receptors in the analgesic action of gossypin. |
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| Keywords: | Gossypin Analgesia Opiate receptor |
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