愈肝汤对慢性乙肝患者脂质过氧化的影响

目的　探讨愈肝汤对慢性乙肝患者的脂质过氧化作用。方法　 43例慢性乙肝患者服愈肝汤治疗 3mo ,观察其治疗前后超氧化物歧化酶 (SOD)、谷胱甘肽过氧化物酶 (GSH -Px)活力和过氧化脂质(LPO)水平的变化 ,并与 38例健康对照组比较。结果　慢性乙肝患者SOD、GSH -Px活力降低 (P <0 .0 5 ) ,LPO水平升高 (P <0 .0 5 ) ;愈肝汤可升高SOD和GSH -Px酶活性 (P <0 .0 1) ,降低LPO水平 (P <0 .0 5 )。结论　愈肝汤对慢性乙肝患者有明显的抗脂质过氧化作用 ,这是其治疗慢性乙型肝炎、减轻肝细胞损伤的重要机理之一。

Affection of Yugan decoction on lipid peroxydation in patients with chronic hepatitis B

Objective To study the effects of against lipid peroxidation of yugan decoction (愈肝汤)in patients with chronic hepatitis B(CHB).Methods Forty three CHB patients were treated by yugan decoction for three month,the activities of superoxide dismutase (SOD)and glutathione peroxydase (GSH-Px) and level of lipid peroxide (LPO) were measured before and aftor treatment,and compared with 38 healthy subjects.Results The activities of SOD and GSH-Px were reduction and the level of LPO was elevation (P<0.05).Conclusion The yugan decoction possesses effect of against lipid peroxidation in CHB patients,and that may be one of importent mechenisms for treatment of CHB and deminish the hepatocellular injery in CHB patients.