Central effects of baclofen on thel-dopa induced hyperactive urinary bladder of the rat |
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Authors: | U. Sillén B. Persson A. Rubenson |
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Affiliation: | (1) Department of Pediatric Surgery, Östra sjukhuset, S-416 85 Göteborg, Sweden;(2) Department of Pharmacology, University of Göteborg, S-400 16 Göteborg, Sweden |
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Abstract: | Summary Cystometric recordings were performed in pentobarbitone anaesthetized rats and the effects of baclofen on urinary bladder function were evaluated as their influence on bladder hyperactivity induced by 1-dihydroxyphenylalanine (l-dopa) after peripheral decarboxylase inhibition. The bladder response was inhibited by intracerebroventricularly (i.c.v., 4th ventricle, 0.1 g) as well as by systemically administered (10 mg/kg i.v.) baclofen. Intravenous naloxone but not i.v. bicuculline i.c.v. substance P or i.c.v. glutamate antagonized the inhibitory actions of i.c.v. or/and i.v. baclofen.It is suggested that baclofen depresses the hyperactive bladder by a central action that is unrelated to bicuculline sensitive gamma aminobutyric acid mechanisms, substance P or glutamate neurotransmission but that is possibly related to interference with opioid mechanisms. |
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Keywords: | Urinary bladder font-variant:small-caps" >l-Dopa Baclofen Naloxone |
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