神经节苷脂治疗新生儿缺氧缺血性脑病42例 |
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引用本文: | 马海欣,闫文,张红爱,于淑群.神经节苷脂治疗新生儿缺氧缺血性脑病42例[J].陕西医学杂志,2008,37(9). |
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作者姓名: | 马海欣 闫文 张红爱 于淑群 |
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作者单位: | 西安市儿童医院新生儿科,西安,710002 |
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摘 要: | 目的:探讨单唾液酸四己糖神经节苷脂(GM1)治疗新生儿缺氧缺血性脑病(HIE)的疗效。方法:将83例HIE患儿随机分为治疗组和对照组,均给予常规治疗,治疗组在此基础上应用GM1,每次20mg,每天1次,10~14d为1个疗程。通过比较两组患儿神经症状恢复时间和新生儿行为神经评分(NBNA)来判断药物疗效。结果:治疗后两组患儿神经症状恢复时间和NBNA评分经统计学处理,均具有显著性差异(P<0.05),治疗组疗效优于对照组。结论:GM1治疗HIE疗效好,能促进临床症状缓解,缩短病程,提高治愈率。
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关 键 词: | 缺氧缺血 脑/药物疗法 神经节苷脂(GM1)/治疗应用 婴儿 新生 |
Observation of clinical curative effect of ganglioside for 42 neonate with hypoxic ischemic encephalopathy |
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Abstract: | Objective:To explore the curative effect of monosialotetrahexosyl ganglioside for treating neonatal hypoxic ischemic encephalopathy(HIE). Methods: 83 cases of HIE were divided into treatment group and control group randomly,and both groups received conventional therapy. Injection of ganglioside was added in the treatment group , 20mg each time, 10~14 days as a course of treatment。After treatment,the neonate were evaluated by recovery time of nerve symptom recovery and NBNA. Results: Treatment group surpasses control group in recovery time of nerve symptom recovery and NBNA ,there is significant difference between two groups(P<0.05).Conclusion : GM1 can relieve clinical symptom ,shorten course of disease and increase cure rate , GM1 has ideal curative effect on neonatal HIE. |
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Keywords: | Hypoxic-ischemic brain/ drug therapy Ganliosides (GM1) /therapeutic use Infant newborn |
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