Bobel-24 activity against Cryptosporidium parvum in cell culture and in a SCID mouse model |
| |
| Authors: | Rueda Cristina Fenoy Soledad Simón Fernando Del Aguila Carmen |
| |
| Affiliation: | Sección de Parasitología, Departamento de Bioquímica, Biología Celular y Molecular, Facultad de Farmacia, Universidad San Pablo CEU, Urbanización Montepríncipe, Ctra. Boadilla del Monte km 5,300, 28668 Madrid, Spain. |
| |
| Abstract: | The anticryptosporidial activity of Bobel-24 (2,4,6-triiodophenol) was studied for the first time, resulting in a reduction of the in vitro growth of Cryptosporidium of up to 99.6%. In a SCID mouse model of chronic cryptosporidiosis, significant differences (P < 0.05) in oocyst shedding were observed in animals treated with 125 mg/kg/day. These results merit further investigation of Bobel-24 as a chemotherapeutic option for cryptosporidiosis. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
