| B族维生素对60例奥沙利铂神经毒性预防的临床观察 |
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| 引用本文： | 徐德洲.B族维生素对60例奥沙利铂神经毒性预防的临床观察[J].青海医药杂志,2005,35(12):13-14. |
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| 作者姓名： | 徐德洲 |
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| 作者单位： | 江苏省仪征市人民医院药剂科,211400 |
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| 摘 要： | 目的：通过B族维生素神经的营养机制观察对奥沙利铂神经毒性的预防治疗作用。方法：对120例应用5-Fu,CF及奥沙利铂联合化疗病人，随机分为两组，一组给予VitB1、VitB6各（0．2～0．5）g，观察神经毒性和毒性出现持续时间。结果：加用B族维生素组末梢神毒性作用减弱或消退。结论：大剂量B族维生素治疗后末梢神经毒性出现时间明显延迟且症状持续时间短。
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| 关 键 词： | 奥沙利铂 神经毒性 B族维生素 |
Protecting Effects of Vitamin B Series and Neurotoxicity Induced-oxaliplatin |
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| Xu Dezhou.Protecting Effects of Vitamin B Series and Neurotoxicity Induced-oxaliplatin[J].Qinghai Medical Journal,2005,35(12):13-14. |
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| Authors: | Xu Dezhou |
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| Institution: | Xu DezhouThe People's Hospital of Yizheng City |
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| Abstract: | Objective: To characterize the effectiveness of vitamin B series against neurotoxicity induced-oxaliplatin.Methods: A total of 120 patients with gastrointestinal cancer were designed to the control group and the test group in which patients received the chemotherapy with 5-Fu+CF+oxaliplatin after they experienced a great number of vitamin B1 and B6 treatment.Results: The neurotoxicity of peripheral nerve showed faint and delayed.Conclusions: A great number of vitamin B series can week and delay the peripheral neurotoxicity. |
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| Keywords: | Vitamin B Neurtoxicity Peripheral nerve Cancer Chemotherapy Oxaliplatin |
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