胡芦巴提取物对实验性糖尿病大鼠的降血糖作用

目的：探讨胡芦巴提取物作用不同时间实验性糖尿病大鼠血糖的变化。方法：采用链脲佐菌素制备糖尿病大鼠模型，随机分为糖尿病组(D)8只、胡芦巴提取物治疗组(F) 10只,另设正常对照组(C) 6只，观察胡芦巴提取物作用不同时间糖尿病大鼠血糖的变化。结果：与糖尿病组比较，给予胡芦巴提取物治疗组糖尿病大鼠血糖第9天开始明显下降（P<0.05），第21天（3周）时血糖显著降低（P<0.01）；第27天(4周)左右降至与对照组同样水平（P>0.05），给药4周内血糖水平随治疗时间延长而降低，呈负相关关系（r =-0.97，P<0.05）。4～12周血糖水平保持平稳，血糖水平不随时间延长而改变。胡芦巴提取物治疗组给药4周后停给2周，停止给药期间血糖回升较缓慢。结论：胡芦巴提取物能明显降低糖尿病大鼠血糖含量，使其恢复到正常大鼠血糖水平，并在给药4周内呈明显的时效关系。

Time-effect relationship of hypoglycemic effect of fenugreek seed extracts on experimental diabetic rats

Objective To study the time-effect relationship of hypoglycemic effect of fenugreek seed extracts on experimental diabetic rats.Methods The diabetic models were established by using streptozotocin(STZ) in rats.All the rats were randomly divided into three groups:diabetic control group(D)(n=8),fenugreek seed extracts treatment group(F)(n=10),and normal control group(C)(n=6).The time-effect of the blood glucose level was observed.Results Compared with group D,on the 9th day the level of the blood glucose decreased significantly in diabetic rats treated with fenugreek seed extracts(P<0.05),on the 21st day it decreased significantly (P<0.01).On the 27th day approximately it decreased to normal level(P>0.05) and kept this low level to the 12th week.In the first 4 weeks the level of blood glucose in diabetic rats was negatively related with treatment times of fenugreek seed extracts(r=-0.97,P<0.05),and hypoglycemic effect increased correspondingly with the time of treatment.After treatment for 4 weeks and withdrawal for 2 weeks,the level of blood glucose increased lowly.Conclusion Fenugreek seed extracts can reduce significantly the level of blood glucose in diabetic rats and recover it to the normal level with the relations of time-effect.