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| 鬼臼毒素DPPC脂质体凝胶剂的制备方法及检测 | |
| 引用本文： | 后桂荣,曾抗,李国锋,杨德忠.鬼臼毒素DPPC脂质体凝胶剂的制备方法及检测[J].中国医学物理学杂志,2003,20(2):97-98. |
| 作者姓名： | 后桂荣 曾抗 李国锋 杨德忠 |
| 作者单位： | 1. 第一军医大学南方医院,皮肤科,广东,广州,510515 2. 第一军医大学南方医院,药学部,广东,广州,510515 3. 广州军区联勤部,药品仪器检验所,广东,广州,510500 |
| 基金项目： | 国家自然科学基金资助项目(39970680) |
| 摘 要： | 目的：制备一种含有鬼臼毒素DPPC脂质体凝胶剂，用于治疗和预防尖锐湿疣的复发。材料和方法：用逆向蒸发法制备药物，光镜和电镜观察其形态。用凝胶渗透色层技术测得脂质体的包封率。结果：鬼臼毒素DPPC脂质体光镜下可见球形脂质体．其平均粒径为187nm；电镜下DPPC脂质体的结构是多层多室脂质体。包封率为73．8％。结论：使用逆向蒸发法制备脂质体使其分布较均匀，方法简便易行，其包封率较高。 |
| 关 键 词： | 鬼臼毒素 脂质体 凝胶剂 制备 检测 治疗 预防 尖锐湿疣 复发 二棕榈酰磷脂酰胆碱 DPPC |
| 文章编号： | 1005-202X(2003)02-0097-02 |
| 修稿时间： | 2002年9月16日 |
Preparation and examination of podophyllotoxin DPPC liposome gels |
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| HOU Gui-rong,ZENG Kang,LI Guo-feng,YANG De-zhong.Preparation and examination of podophyllotoxin DPPC liposome gels[J].Chinese Journal of Medical Physics,2003,20(2):97-98. | |
| Authors: | HOU Gui-rong ZENG Kang LI Guo-feng YANG De-zhong |
| Institution: | HOU Gui-rong1,ZENG Kang1,LI Guo-feng2,YANG De-zhong3 |
| Abstract: | Objective: We prepared a gels which contain podophyllotoxin DPPC liposome, and it was used to treat and prevent the relapse of CA (Condyloma Accuminatum). Materials and methods: Prepared the liposome with the method after reverse evaporation technique, then its appearances was detected by optic and electronic microscope, and its embedding ratio was examined by gel filtration. Results: When podophyllotoxin DPPC liposome was detected by optic microscope, the global liposome was found, and the average diameter is 187nm. Under electronic microscope, it was multilayer and multichamber. The embedding ratio is 73.8%. Conclusion: The distribution of gels which we prepared is more uniformity, the method of preparation is simple, and the embedding ratio is higher. |
| Keywords: | podophyllotoxin liposome preparation gel |
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