Differential Associations of 6 Adiposity Indices With Dementia in Older Adults: The MIND-China Study |
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| Institution: | 1. Department of Neurology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, PR China;2. Department of Neurology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, PR China;3. Shandong Provincial Clinical Research Center for Neurological Diseases, Jinan, Shandong, PR China;4. Aging Research Center and Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet-Stockholm University, Stockholm, Sweden;1. Department of Family Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea;2. Department of Family Medicine, Yongin Severance Hospital, Yongin-si, Gyeonggi-do, Republic of Korea;3. Department of Healthcare Administration and Policy, School of Community Health Sciences, University of Nevada, Las Vegas, NV, USA;1. Columbia University School of Nursing, New York City, NY, USA;2. University of Pennsylvania School of Nursing, Philadelphia, PA, USA;3. Center for Home Care Policy & Research, VNS Health, New York, NY, USA;4. Department of Biobehavioral Health Sciences, NewCourtland Center for Transitions and Health, University of Pennsylvania School of Nursing, Philadelphia, PA, USA;5. The University of Utah College of Nursing, Salt Lake City, UT, USA;6. Data Science Institute, Columbia University, New York City, NY, USA |
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| Abstract: | ObjectivesThe cross-sectional association between late-life obesity and dementia is often explained by the obesity paradox. We assessed the potential differential associations of various adiposity indices with dementia and subtypes of dementia in rural Chinese older adults.DesignA population-based cross-sectional study.Setting and ParticipantsA total of 5277 participants (age ≥60 years; 57.23% female) who were living in rural communities and were examined in March–September 2018 for MIND-China.MethodsWe used weight, height, and waist circumference (WC) to calculate 6 adiposity indices: body mass index (BMI), waist-to-height ratio (WHtR), weight-adjusted-waist index (WWI), A Body Shape Index (ABSI), body roundness index (BRI), and Conicity Index (ConI). Dementia, Alzheimer's disease (AD), and vascular dementia (VaD) were clinically diagnosed following the international criteria. Data were analyzed with logistic regression models.ResultsOf the 5277 participants, 303 were diagnosed with dementia, including 193 with AD and 99 with VaD. The multivariable-adjusted odds ratio (95% CI) of dementia associated with the highest (vs lowest) quintile of adiposity index was 2.32 (1.40–3.85) for WWI, 1.56 (1.03–2.36) for ABSI, and 1.40 (0.92–2.11) for ConI. Similarly, higher levels of these 3 adiposity indices were significantly associated with an increased likelihood of AD, whereas a higher BMI was associated with a decreased likelihood of AD. None of the 6 examined adiposity indices was significantly associated with VaD when adjusting for multiple confounders.Conclusions and ImplicationsThe adiposity index WWI is linearly associated with the likelihood of dementia and AD. An increased WWI may be a clinical marker for the dementia syndrome and Alzheimer's dementia. |
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| Keywords: | Adiposity indices weight-adjusted waist index dementia Alzheimer's disease population-based study |
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