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Evolutionary states and trajectories characterized by distinct pathways stratify patients with ovarian high grade serous carcinoma
Institution:1. Research Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland;2. Department of Pathology, University of Helsinki and HUS Diagnostic Center, Helsinki University Hospital, 00029 Helsinki, Finland;3. Cancer Invasion and Resistance Group, Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen, Denmark;4. Cancer Research Unit, Institute of Biomedicine and FICAN West Cancer Centre, University of Turku, 20014 Turku, Finland;5. Department of Obstetrics and Gynaecology, University of Turku and Turku University Hospital, 200521 Turku, Finland;6. Biotech Research and Innovation Centre, University of Copenhagen, 2200 Copenhagen, Denmark;7. Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark
Abstract:
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  • Keywords:Cancer  Tumor evolution  Integrative analysis  Ovarian cancer  Tumor heterogeneity  PI3K/AKT  Prospective cohort  Multiregion sampling  Organoid experiments  Evolutionary trajectories
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