广东地区无代谢性疾病自然人群脂联素参考值的建立

目的通过检测广东地区无代谢性疾病自然人群脂联素水平,建立脂联素参考值。方法选取2018年12月至2019年10月在中山大学孙逸仙纪念医院健康体检中心和东莞市社区收集的1156例无代谢性疾病自然人群为研究对象。所有受试者均进行人体学测量和空腹血糖、糖化血红蛋白及其他生化指标检测。采用胶乳增强免疫比浊法检测脂联素水平,分析其在无代谢性疾病自然成年人群参考值,并根据性别、年龄和体质指数分组,比较各组别间脂联素差别。相关数据分析采用多因素线性回归分析。结果将脂联素>P25范围定义为参考值,在本研究中总人群脂联素参考值为:>3.2 mg/L;男性参考值为:>3.0 mg/L;女性参考值为:>3.4 mg/L。多因素线性回归分析显示,脂联素受年龄、收缩压、甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇影响(标准化回归系数β=0.037、-0.012、-1.316、1.994、-0.463,均P<0.05)。结论本研究初步建立了基于广东地区无代谢性疾病自然成年人群的脂联素参考值,为后续深入探讨脂联素的临床意义奠定了基础。

Reference range of adiponectin for metabolic disease-free population in Guangdong China

Objective Establishing the reference range of adiponectin by detecting the levels of adiponectin in the population free of metabolic disease in Guangdong China.Methods A total of 1156 individuals were collected from Sun Yat-sen Memorial hospital Healthy Examination Center and Dongguan communities,from December 2018 to October 2019.All individuals were collected anthropometric information and biochemical indicators,such as fasting blood glucose and glycated hemoglobin.Adiponectin was detected by latex-enhanced immunoturbidimetry,and its distribution in metabolic diseases-free population was analyzed to establish reference range.The distributions of adiponectin according to gender,age and body mass index were analyzed.Multiple linear regression were performed to analyze the relationship between adiponectin and indicators.Results We defined adiponectin reference range was>P25 and the reference value were>3.2 mg/L for total population,>3.0 mg/L for male population and>3.4 mg/L for female population,respectively.Multivariate linear regression analysis showed that adiponectin was effected by age,systolic blood pressure,triglycerides,high-density lipoprotein cholesterin and low-density lipoprotein cholesterin(standardized regression coefficientβ=0.037,-0.012,-1.316,1.994,-0.463,all P<0.05).Conclusion This study initially established reference values for adiponectin based on diseases-free natural population in Guangdong China,which is important for further exploration of the clinical values of adiponectin.