YpT1-2N0 rectal cancer after neoadjuvant chemoradiation has lower survival compared with pT1-2N0 rectal cancer |
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| Authors: | Jue-feng Wan Ji Zhu Gui-chao Li Wen-jie Sun Zhen Zhang |
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| Affiliation: | 1. Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China;2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China |
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| Abstract: | Pathologic T1-2N0 rectal cancer shows an excellent prognosis without preoperative or postoperative chemoradiation. However, oncologic outcome of ypT1-2N0 remains unclear and undetermined. Thus, the aim of this study was to compare the survival of ypT1-2 and pT1-2 rectal cancer patients after radical resection and identify risk factors of ypT1-2 rectal cancer in Surveillance, Epidemiology, and End Results Program (SEER)-registered rectal cancer patients. The results showed that ypT1-2N0 rectal cancer after neoadjuvant chemoradiation has lower survival compared with pT1-2N0 rectal cancer and mucinous/signet-ring cancer and less than 12 lymph nodes retrieval were two risk factors in ypT1-2 patients. These results suggest that ypT1-2 patients with one or two risk factors may benefit from postoperative adjuvant chemotherapy. |
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| Keywords: | rectal cancer adjuvant chemotherapy risk factors good response SEER |
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