The prognostic value of peripheral CD4+CD25+ T lymphocytes among early stage and triple negative breast cancer patients receiving dendritic cells-cytokine induced killer cells infusion |
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Authors: | Qing-Kun Song Jun Ren Xin-Na Zhou Xiao-Li Wang Guo-Hong Song Li-Jun Di Jing Yu Amy Hobeika Michael A Morse Yan-Hua Yuan Hua-Bing Yang Herbert Kim Lyerly |
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Institution: | 1. Beijing Key Laboratory of Therapeutic Cancer Vaccines, Capital Medical University Cancer Center, Beijing Shijitan Hospital, Beijing 10038, China;2. Department of Medical Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China;3. Department of Surgery, Duke University Medical Center, Durham, NC 27710, United States;4. Department of Medicine, Duke University Medical Center, Durham, NC 27710, United States |
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Abstract: | ObjectiveThis study aimed to assess the prognostic value of CD4+CD25+ T lymphocyte in peripheral blood among breast cancer patients treated with adoptive T lymphocytes immunotherapy.Methods217 patients participated in the follow-up study. CD4+CD25+ proportion was measured by flow cytometry in peripheral T cells. The median survival was estimated by Kaplan-Meier curve, Log-rank test and Cox hazard proportion regression model, between groups of CD4+CD25+ proportion more than 5% and less than or equal to 5% in peripheral T cells.ResultsPeripheral CD4+CD25+ T lymphocytes had not a relationship with progression-free survival. It was featured that above 5% peripheral CD4+CD25+ proportion of T cells was related with the median overall survival by a shorten of 51 months (p < 0.05) with the HR 1.65 (95%CI 1.04, 2.62). Above 5% CD4+CD25+proportion of T cells produced the HR to be 1.76 (95%CI 1.07, 2.87) In stage 0-II patients, and 3.59 (95%CI 1.05, 12.29) in triple negative breast cancer patients.ConclusionCellular immunity restoration recovered by adoptive T cell infusions which resulted in less proportion of peripheral CD4+CD25+T lymphocytes could be a potential prognostic indicator among early stage and triple negative patients. |
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Keywords: | CD4+CD25+ T lymphocyte early stage breast cancer triple negative breast cancer prognosis adoptive cell therapy |
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