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Cutaneous Neurofibroma Heterogeneity: Factors that Influence Tumor Burden in Neurofibromatosis Type 1
Affiliation:1. Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA;2. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA;3. Biosciences Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom;4. NIHR Newcastle Biomedical Research Center Dermatology, Newcastle University, Newcastle Upon Tyne, United Kingdom;5. Hereditary Cancer Group, Germans Trias i Pujol Research Institute (IGTP), Barcelona, Spain;6. Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, Michigan, USA;7. Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA;8. Division of Hematology and Oncology, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA;9. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA;10. Comprehensive Neurofibromatosis Clinic, University of Texas Southwestern Medical Center, Dallas, Texas, USA;11. Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA;12. O’Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Abstract:
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  • Keywords:cNF  cutaneous neurofibroma  ECM  extracellular matrix  GEM  genetically engineered mouse  KO  knockout  LOH  loss of heterozygosity  MEK  MAPK/extracellular signal–regulated kinase kinase  MPNST  malignant peripheral nerve sheath tumor  NF1  neurofibromatosis type 1  pNF  plexiform neurofibroma
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