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T cell immune deficiency rather than chromosome instability predisposes patients with short telomere syndromes to squamous cancers
Institution:1. Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA;2. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA;3. Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA;4. Telomere Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA;5. Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA;6. Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA;7. Abramson Cancer Center, Perlman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
Abstract:
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  • Keywords:telomerase  aging  T cell aging  genome instability  head and neck cancer  senescence  immune aging  pulmonary fibrosis
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