儿童脑性疾病血清痕量元素变化及其临床意义

目的　探讨脑性疾病儿童血清痕量元素的变化及其意义。方法　 88例儿童分为四组 ,A为健康儿童对照组 ,B为高热惊厥组 ,C为无热惊厥组 ,D为智力低下组。采用原子吸收分光光度法测定各组血清痕量元素水平 ,并进行比较。结果　热性惊厥组患儿血清铜、锌水平明显较对照组低 (P <0 .0 5 ) ,无热惊厥组患儿血清铜水平升高 (P <0 0 5 ) ,智力低下组患儿血清铜水平也较对照组高 (P <0 0 5 )且锰水平明显升高 (P <0 0 1)。各组血清铁水平无显著差异。结论　痕量元素铜、锌的缺乏可能是儿童易发作热性惊厥的原因之一 ,而铜和锰过高则与非热性惊厥和智力低下的发病有密切关系

Changes of trace elements in the serum of children brain diseases and their clinical significance

Objective Objective To investigate the transformation and significance of trace elements of children with brain diseases.Methods 88 cases were divided into four groups. Group A: control group; Group B: febrile convulsions; Group C: epilepsy; Group D: dementia. Trace elements concentrations in the serum of children with brain diseases were determined by Atomic Absorption Spectrophotometry and compared. Results Serum Copper and Zinc levels of group B were lower than those of control group($P$<0.05). Serum Copper levels of group C and group D were higher than that of control group($P$<0.05). Serum Manganese level of group D was significantly higher than that of control group ($P$<0.01). There was no difference in ion among all groups. Conclusion Deficiency of Copper and Zinc is one of the reasons why some children are susceptible to febrile convulsions. Manganese and Copper overload is significantly relative to dementia and epilepsy.