肠外肠内高营养治疗溃疡性结肠炎112例的疗效

目的探讨肠外营养(parenteral nutrition,PN)及肠内营养(enteral nutrition,EN)治疗溃疡性结肠炎(ulcerative colitis,UC)的疗效。方法对解放军第三〇九医院收治的112例UC患者进行前瞻性分析,随机分为观察组(PN+EN)及对照组(常规内科治疗)。两组均接受4周治疗,4周后对各组治疗前后的白蛋白(ALB)、前白蛋白(PA)、总蛋白(TP)、体质量指数(BMI)进行对比,并对两组治疗效果进行对比分析。结果共112例患者纳入本次研究,观察组和对照组各56例。观察组经EN+PN治疗4周后总有效率83.9%,与对照组相比,差异有统计学意义(P0.05);与对照组比较,观察组治疗后TP[(65.32±6.78)g/L vs(59.81±6.98)g/L,P0.05]、PA[(267.23±63.48)g/L vs(245.38±57.39)g/L,P0.05)]、ALB[(36.2±6.89)g/L vs(29.2±5.79)g/L,P0.05]、BMI[(23.45±3.02)kg/m2vs(21.34±3.07)kg/m2,P0.05]均有明显的增高。结论对UC患者进行肠外肠内高营养治疗的效果较好,值得在临床上推广。

Randomized controlled study of parenteral and enteral nutrition in the treatment of ulcerative colitis

Objective To investigate the efficacy of parenteral nutrition （PN） and enteral nutrition （EN） in the treatment of ulcerative colitis （UC）. Methods One hundred and twelve patients with UC from Jan. 2012 to Sep. 2013 in the 309 Hospital were randomly divided into the PN ＋ EN group （56 cases） and the conventional medical therapy group （56 cases）. Both groups received 4 weeks of treatment, after 4 weeks, albumin （ALB）, prealbumin （ PA）, total protein （TP） and body mass index （BMI） were compared between two groups. Results After 4 weeks＇ treatment by the PN ＋ EN, the total efficiency was 83.9% , compared with the control group, the difference was statistically signifi- cant （P 〈 0.05 ）. Compared with control group, the ALB [ （36.2 ± 6.89） g/L vs （29.2 ± 5.79） g/L, P 〈 0.05 ], TP [（65.32±6.78） g/Lvs （59.81±6.98） g/L, P〈0.05], PA [（267.23±63.48） g/Lvs （245.38±57.39） g/L, P 〈 0.05 ] and BMI [ （23.45 ± 3.02） k/m2 vs （21.34 ± 3.07 ） kg/m/, P 〈 0.05 ] in PN ＋ EN group were significant- ly improved. Conclusion The efficacy of parenteral and enteral nutrition therapy in patients with UC has a good effect and can significantly alter the patient＇ s condition, it is worth in clinical practice.