益肾化湿颗粒治疗糖尿病肾病的效果及对肾小管损伤的影响

目的探究益肾化湿颗粒对糖尿病肾病(DN)的治疗效果及对患者肾小管损伤的影响。方法选取我院2018年1月~2019年1月收治的DN患者200例,按患者的治疗意愿分为对照组与观察组各100例。其中对照组的患者使用常规降糖、降血脂药物治疗,观察组在对照组的基础上联合益肾化湿颗粒治疗,两组疗程均为4个月。比较两组治疗前与治疗4个月后的血糖指标[空腹血糖(FGB)、餐后2h血糖(2hPG)、糖化血红蛋白(HbAlc)];肾功能指标[血清肌酐(Scr)、尿素氨(BUN)、尿蛋白排泄速率(UAER)]以及肾小管功能指标[β2微球蛋白(β2-MG)、视黄醇结合蛋白(RBP)、N-乙酰-β-D葡萄糖苷酶(NAG)]的结果变化。结果两组患者治疗4个月后的FGB、2hPG、HbAlc、Scr、BUN、UAER、β2-MG、RBP、NAG指标均比治疗前降低(P均<0.05);且观察组上述指标均显著低于对照组(P<0.05)。结论益肾化湿颗粒可有效控制DN患者血糖与血压水平,改善其肾功能、减轻肾小管损伤。

Effects of Yishen Huashi Granule on Diabetic Nephropathy and its Influence on Renal Tubular Injury

Objective To explore the therapeutic effects of Yishen Huashi granule on diabetic nephropathy(DN)and its influence on renal tubular injury.Methods A total of 200 patients with DN admitted to our hospital from January 2018 to January 2019 were selected.According to the treatment willingness of patients,the patients were divided into control group and observation group,with 100 cases in each group.Control group was treated with conventional hypoglycemic and hypolipidemic drugs,and observation group was combined with Yishen Huashi granule on the basis of control group,and the two groups were treated for 4 months.Blood glucose indexes[fasting blood glucose(FBG),postprandial 2h blood glucose(2hPG),glycosylated hemoglobin(HbAlc)],renal function indicators[serum creatinine(Scr),blood urea nitrogen(BUN),urinary albumin excretion rate(UAER)]and renal tubular function indicators[β2 microglobulin(β2-MG),retinol binding protein(RBP),N-acetyl-β-D glucosidase(NAG)]were compared between the two groupsbefore treatment and after 4 months of treatment.Results The FGB,2hPG,HbAlc,Scr,BUN,UAER,β2-MG,RBP and NAG in the two groups after 4 months of treatment were lower than those before treatment(all P<0.05).The above indexesin observation groupwere significantly lower than those in control group(P<0.05).Conclusion Yishen Huashi granule can effectively control blood glucose and blood pressure of DN patients,improve the renal function and reduce renal tubular injury.