血浆可溶性髓样细胞触发受体1对成人脓毒症患者诊断价值的Meta分析

目的评价血浆可溶性髓样细胞触发受体1（sTREM-1）对成人脓毒症患者的诊断价值。 方法检索PubMed、Embase、Cochrane图书馆、中国生物医学文献数据库（CBM）、中国期刊全文数据库（CNKI）、万方数据库和中文科技期刊全文库（VIP）数据库从建库至2017年5月发表的有关血浆sTREM-1对成人脓毒症患者诊断价值的文献。采用双变量模型计算合并诊断比值比（DOR）、合并敏感度、合并特异度、合并阳性似然比（PLR）及合并阴性似然比（NLR）。进行合并受试者工作特征（SROC）曲线,获得曲线下面积（AUC）。 结果最终纳入30篇文献,共3 349例患者。Meta分析显示,合并DOR为20.0395%置信区间（CI）（12.20,32.87）]、合并敏感度为0.8295% CI（0.77,0.86）]、合并特异度为0.81 95% CI（0.76,0.85）]、合并PLR为4.36 95% CI（3.37,5.64）]、合并NLR为0.2295%CI（0.16,0.29）]。SROC曲线显示合并AUC为0.8995%CI（0.85,0.91）]。 结论血浆sTREM-1对诊断成人脓毒症患者具有中度诊断价值。

Diagnostic value of plasma soluble triggering receptor expressed on myeloid cells-1 for adult patients with sepsis: a meta-analysis

ObjectiveTo investigate the diagnostic value of plasma soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) as a biomarker for adult patients with sepsis. MethodsRelated studies on the diagnostic value of plasma sTREM-1 in adult patients with sepsis were searched in PubMed, Embase, Cochrane, CBM, CNKI, Wangfang and VIP published up to May 2017. The bivariate model was used to calculate the pooled diagnostic odds ratio (DOR), pooled sensitivity, pooled specificity, pooled positive likelihood ratio (PLR), and pooled negative likelihood ratio (NLR). The area under the summary receiver operating characteristic (SROC) curve was analyzed. ResultsThirty eligible articles involving 3 349 patients were included. Meta-analysis in total population showed that the pooled DOR was 20.03 95% confidence interval (CI) (12.20, 32.87)]; the pooled sensitivity was 0.82 95% CI (0.77, 0.86)]; the pooled specificity was 0.81 95%CI (0.76, 0.85)]; the pooled PLR was 4.36 95%CI (3.37, 5.64)]; the pooled NLR was 0.22 95%CI (0.16, 0.29)]. The SROC curve showed that the pooled AUC was 0.89 95%CI (0.85, 0.91)]. ConclusionPlasma sTREM-1 has a moderate value in the diagnosis of adult patients with sepsis.