血脂控制水平与PCI术后再狭窄的相关性分析

目的分析血脂控制水平与经皮冠状动脉介入(PCI)术后再狭窄的相关性。方法选取2016年3月-2018年3月我院收治的行PCI术的冠心病患者60例为研究对象,术后3个月行冠状动脉造影复查,根据有无再狭窄分为再狭窄组(n=28)和无狭窄组(n=32),比较两组一般资料、PCI前和PCI术后复查时的血脂水平,并对各影响因素进行相关性分析。结果再狭窄组的吸烟比例、糖尿病比例比无狭窄组更高;观察组复查时总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白水平均与PCI术前无明显差异(P均>0.05),而无狭窄组总胆固醇、甘油三酯、低密度脂蛋白水平比PCI术前显著降低,且低于PCI术后复查时再狭窄组,高密度脂蛋白较前明显升高,且高于PCI术后复查时再狭窄组(P均<0.05)。多因素分析显示,吸烟、合并糖尿病、PCI术后复查时总胆固醇、甘油三酯、低密度脂蛋白水平未下降,高密度脂蛋白未升高是PCI术后再狭窄的独立危险因素。结论 PCI术后总胆固醇、甘油三酯、低密度脂蛋白水平未下降,高密度脂蛋白未升高是PCI术后再狭窄的独立危险因素。

Correlation between Serum Lipid Control Level and Restenosis after PCI

Objective To analyze correlation between serum lipid control level and restenosis after percutaneous coronary intervention(PCI). Methods 60 patients with coronary heart disease(CHD) who underwent PCI and were admitted to the hospital from March 2016 to March 2018 were enrolled. At 3 months after surgery, they underwent coronary angiography for reexamination. They were divided into restenosis group(n=28) and non-stenosis group(n=32) according to presence or absence of restenosis. The general data, serum lipid level before and after PCI were compared between the two groups. Correlation analysis was performed on all influencing factors. Results The proportion of smoking and diabetes in restenosis group was higher than that in non-stenosis group. There was no significant difference in total cholesterol, triglyceride, low-density lipoprotein or high-density lipoprotein level in restenosis group at reexamination time and before PCI(P>0.05). The levels of total cholesterol, triglyceride and low-density lipoprotein in non-stenosis group were significantly lower than those before PCI, which were lower than those in restenosis group after PCI.The high-density lipoprotein was significantly higher than that before PCI, which was higher than that in restenosis group after PCI(P<0.05). Multivariate analysis showed that smoking, diabetes, no decreasing in total cholesterol, triglyceride and low-density lipoprotein levels after PCI, and no increasing in high-density lipoprotein were independent risk factors of restenosis after PCI. Conclusion No decreasing in total cholesterol, triglyceride and low-density lipoprotein levels after PCI, and no increasing in high-density lipoprotein are independent risk factors of restenosis after PCI.