Cyclooxygenase inhibitory flavonoids from the stem bark of Semecarpus anacardium Linn |
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| Authors: | Selvam C Jachak Sanjay M Bhutani K K |
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| Affiliation: | Department of Natural Products, National Institute of Pharmaceutical Education and Research, Punjab, India. |
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| Abstract: | The ethyl acetate extract of stem bark of Semecarpus anacardium showing in vivo anti-in fl ammatory activity in carrageenan induced rat paw edema assay was investigated in order to identify its active compounds. Chemical investigation of the ethyl acetate extract of S.anacardium afforded 3,4,2',4'-tetrahydroxychalcone (butein) and 7,3',4'-trihydroxy fl avone. Evaluation of COX-1 inhibitory activity of 3,4,2',4'-tetrahydroxychalcone and 7,3',4'-trihydroxy fl avone provided the IC(50) values of 28.4 and 36.7 micro M respectively. Further investigation of these compounds for COX-2 inhibitory activity revealed moderate potency towards this enzyme. |
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| Keywords: | Semecarpus anacardium cyclooxygenase‐1 (COX‐1) cyclooxygenase‐2 (COX‐2) anti‐inflammatory activity 3,4,2′,4′‐tetrahydroxychalcone, butein 7,3′,4′‐trihydroxyflavone |
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