| 麦冬多糖MDG-1对糖尿病小鼠模型的降糖作用 |
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| 引用本文： | 王源,王硕,王令仪,从文娟,冯怡.麦冬多糖MDG-1对糖尿病小鼠模型的降糖作用[J].上海中医药大学学报,2011(4):66-70. |
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| 作者姓名： | 王源 王硕 王令仪 从文娟 冯怡 |
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| 作者单位： | 上海中医药大学中药现代制剂技术教育部工程研究中心; |
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| 基金项目： | 国家自然科学基金资助项目(81073065); 国家科技重大专项(重大新药创制)项目(2009ZX09502-009); 上海市教委重点学科建设项目(J50302);上海市教委预算内科研项目(09JW20); 上海市科委科研基金项目(09DZ2292000,09DZ1973000); 上海高校选拔培养优秀青年教师科研专项基金项目(Szy09007) |
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| 摘 要： | 目的:观察麦冬多糖MDG-1对链脲佐菌素(STZ)诱导的糖尿病小鼠的降糖作用。方法:①将雄性C57BL/6小鼠随机分为空白对照组,MDG-1高、中、低剂量给药组,二甲双胍组,考察药物对正常雄性C57BL/6小鼠空腹血糖的影响。②将雄性C57BL/6小鼠随机分为模型对照组,MDG-1高、中、低剂量给药组,二甲双胍组,采用腹腔注射STZ联合高脂饲料诱导复制2型糖尿病小鼠模型,药物干预后测定随机和空腹血糖、口服糖耐量和血清胰岛素水平。结果:各剂量组MDG-1对正常小鼠空腹血糖无影响,对糖尿病小鼠体质量有轻微降低作用;300 mg/kgMDG-1对糖尿病小鼠的随机血糖和空腹血糖均有显著降低效果,并可改善小鼠口服糖耐量和血清胰岛素水平。结论:MDG-1可降低由STZ诱导得到的糖尿病小鼠血糖,并对改善其胰岛素抵抗有一定作用。
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| 关 键 词： | 麦冬多糖 2型糖尿病 小鼠模型 降血糖 胰岛素抵抗 |
Hypoglycemic Effects of Polysaccharide MDG-1 from Ophiopogon japonicus on Diabetes Model Mice |
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| WANG Yuan WANG Shuo WANG Ling-yi CONG Wen-juan FENG Yi Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine.Hypoglycemic Effects of Polysaccharide MDG-1 from Ophiopogon japonicus on Diabetes Model Mice[J].Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai,2011(4):66-70. |
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| Authors: | WANG Yuan WANG Shuo WANG Ling-yi CONG Wen-juan FENG Yi Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine |
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| Institution: | WANG Yuan WANG Shuo WANG Ling-yi CONG Wen-juan FENG Yi Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine |
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| Abstract: | Objective: To investigate the hypoglycemic effects of polysaccharide MDG-1 from Ophiopogon japonicus on diabetes model mice induced by streptozotocin(STZ).Methods:(1) Male C57BL/6 mice were randomly divided into five groups: control group,high,middle,low doses of MDG-1 groups,and metformin(Met) group.The hypoglycemic effects of MDG-1 on the fasting blood glucose(FBG) of normal mice were evaluated.(2) Diabetes mouse model was induced by STZ in combination with high-fat diets.The male C57BL/6 mice were divide... |
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| Keywords: | Ophiopogon japonicas polysaccharide type 2 diabetes mouse model hypoglycemic effect insulin resistance |
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