胃食管反流病中医诊疗方案的疗效验证

目的:验证国家中医药管理局"吐酸病"(胃食管反流病)协作组诊疗方案的临床疗效,为进一步优化该诊疗方案奠定基础。方法:160例胃食管反流病患者按3∶1比例随机分成中药组(n=120)和西药组(n=40)。中药组患者按协作组诊疗方案进行辨证分型治疗,西药组给予奥美拉唑治疗,疗程均为8周。观察并比较两组患者的临床疗效及其胃镜下食管黏膜炎症改善情况。结果:临床总有效率中药组为94.17%,西药组为82.05%,两组比较差异具有统计学意义(P<0.01);胃镜下食管黏膜炎症改善总有效率中药组为55.79%,西药组为56.67%,两组比较差异不具有统计学意义(P>0.05)。结论:国家中医药管理局"吐酸病"协作组诊疗方案治疗胃食管反流病具有较好的临床疗效,可作为该病中医诊断、治疗的规范,供临床医师参考、借鉴。

Verification of Clinical Effects on Traditional Chinese Medical Protocol of Gastroesophageal Reflux Disease

To validate the protocol of diagnosis and treatment of gastroesophageal reflux disease （GERD） designed by ＂Tusuau Disease＂ （GERD） cooperative group of State Administration of Traditional Chinese Medicine （TCM） and further optimize the protocol. Methods： One hundred and sixty patients with GERD were randomly divided into Chinese medicine group （group A, n = 120） and western medicine group （group B, n =40） according to 3：1 ratio. The group A was treated according to the protocol of GERD designed by ＂Tusuan Disease＂ cooperative group and the group B was treated by omeprazole ,with a course of eight weeks. The clinical effects and the endoscopic improvement of inflammation of esophageal mucosa were observed. Results： The clinical total effective rates of group A and group B were 94.17% and 82.05% respectively,with a significant difference between two groups （ P 〈 0.01 ）. The total effective rates of endoscopic improvement of esophageal mueosal inflammation of group A and group B were 55.79% and 56.67% respectively,with no statistical difference between two groups （P 〉0.05）. Conclusion： The protocol of diagnosis and treatment of GERD designed by ＂Tusuan Disease＂ cooperative group of State Administration of TCM has better clinical effects and can be used as the criteria for diagnosis and treatment of GERD.