| 益母草水提物对心室重构大鼠心肌胶原表达的影响 |
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| 引用本文： | 章忱,刘艳,吕嵘,郭炜,卫洪昌. 益母草水提物对心室重构大鼠心肌胶原表达的影响[J]. 上海中医药大学学报, 2011, 0(3): 76-79 |
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| 作者姓名： | 章忱 刘艳 吕嵘 郭炜 卫洪昌 |
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| 作者单位： | 上海中医药大学基础医学院; |
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| 基金项目： | 上海市教委重点学科建设项目(J50301),上海市教委预算内科研项目(2010JW01); 上海市科委重点项目(09JC1413400) |
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| 摘 要： | 目的:从心肌组织胶原表达及代谢的角度观察益母草水提物对大鼠心室重构的影响.方法:SD大鼠随机分为正常组、模型组、依那普利组和益母草水提物组,后3组动物皮下注射异丙肾上腺素(ISO)建立心肌重构模型,以相应药物干预15周.碱水解法检测大鼠心肌羟脯氨酸含量;免疫组化观察心肌组织Ⅰ、Ⅲ型胶原含量及Ⅰ、Ⅲ型胶原比;明胶酶谱法检...
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| 关 键 词： | 益母草 心肌重构 胶原 基质金属蛋白酶-2 |
Effects of Aqueous Extract of Leonurus Heterophyllus on Expression of Myocardial Collagen in Rats of Ventricular Remodeling |
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| ZHANG Chen LIU Yan LV Rong GUO Wei WEI Hong-changBasic Medical School,Shanghai University of Traditional Chinese Medicine. Effects of Aqueous Extract of Leonurus Heterophyllus on Expression of Myocardial Collagen in Rats of Ventricular Remodeling[J]. Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai, 2011, 0(3): 76-79 |
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| Authors: | ZHANG Chen LIU Yan LV Rong GUO Wei WEI Hong-changBasic Medical School Shanghai University of Traditional Chinese Medicine |
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| Affiliation: | ZHANG Chen LIU Yan LV Rong GUO Wei WEI Hong-changBasic Medical School,Shanghai University of Traditional Chinese Medicine |
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| Abstract: | Objective: To investigate the effects of aqueous extract of Leonurus Heterophyllus(LH) on ventricular remodeling in rats from the perspectives of the expression and metabolism of myocardial collagen.Methods: SD rats were randomized into normal group,model group,enalapril group and LH group with corresponding drug intervention for fifteen weeks,and the latter three groups were injected subcutaneously with isoproterenol(ISO) to establish the myocardial remodeling model.The myocardial hydroxyproline contents w... |
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| Keywords: | Leonurus Heterophyllus myocardial remodeling collagen MMP-2 |
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