| 益气增敏方对2型糖尿病大鼠早期肾病的防治作用 |
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| 引用本文： | 薛红丽,张曾,王文健,陈伟华,应健.益气增敏方对2型糖尿病大鼠早期肾病的防治作用[J].上海中医药大学学报,2011(4):71-73. |
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| 作者姓名： | 薛红丽 张曾 王文健 陈伟华 应健 |
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| 作者单位： | 复旦大学附属华山医院中医科; |
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| 基金项目： | 霍英东教育基金会高校青年教师优选资助项目(114036) |
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| 摘 要： | 目的:探讨益气增敏方对2型糖尿病大鼠早期肾病的防治作用。方法:采用高脂饮食联合链脲佐菌素建立稳定的2型糖尿病大鼠早期肾病模型,随机分为模型组、益气增敏方治疗组、氯沙坦对照组、罗格列酮对照组。连续灌胃给药8周,观察治疗前后血糖、血脂、HOMA-IR、尿微量白蛋白(MAU)的变化。结果:益气增敏方可降低糖尿病肾病大鼠的MAU水平,有效改善胰岛素抵抗,降低TG、TC、LDL-c,升高HDL-c水平,还有降低血糖的作用,其疗效优于氯沙坦及罗格列酮。结论:益气增敏方可有效防治2型糖尿病早期肾病,其作用机制与改善糖脂代谢紊乱及胰岛素抵抗有关。
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| 关 键 词： | 益气增敏方 糖尿病肾病 胰岛素抵抗 血脂 尿微量白蛋白 |
Effects of Yiqi Zengmin Recipe on Early Type 2 Diabetic Nephropathy in Rats |
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| XUE Hong-li ZHANG Zeng WANG Wen-jian CHEN Wei-hua YING Jian.Effects of Yiqi Zengmin Recipe on Early Type 2 Diabetic Nephropathy in Rats[J].Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai,2011(4):71-73. |
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| Authors: | XUE Hong-li ZHANG Zeng WANG Wen-jian CHEN Wei-hua YING Jian |
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| Affiliation: | XUE Hong-li ZHANG Zeng WANG Wen-jian CHEN Wei-hua YING Jian Department of Traditional Chinese Medicine,Huashan Hospital Affiliated to Fudan University,Shanghai |
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| Abstract: | Objective: To explore the effects of Yiqi Zengmin Recipe on early type 2 diabetic nephropathy in rats.Methods: The early type 2 diabetic nephropathy rats were induced by the high-fat diets combined with streptozotocin(STZ),and were randomly divided into four groups: model group,Yiqi Zengmin Recipe group,losartan group and rosiglitazone group.After continuous stomach perfusion administration for 8 weeks,the changes of blood glucose,blood lipid,HOMA-IR and MAU were observed.Results: Yiqi Zengmin Recipe could ... |
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| Keywords: | Yiqi Zengmin Recipe diabetic nephropathy insulin resistance blood lipid urinary microalbumin |
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