缺血后处理与线粒体通透性转运孔

背景 缺血后处理(ischemic postconditioning,IPo)能明显减轻器官缺血/再灌注损伤(ischemia/reperfusion injury,I/RI),动物实验和临床研究均已经得到证实,其机制可能与增强组织抗氧化能力和抑制细胞凋亡有关.然而近些年提出线粒体通透性转换孔(mitochondria...

Ischemic postconditioning and mitochondrial permeability transition pore

Background Ischemic postconditioning alleviating ischemia reperfusion injury had been confirmed by experimental study and clinical study.The mechanism involves enhancement of organ antioxidant capacity and inhibition of apoptosis.However,in recent years,it has been put forward that mitochondrial permeability transition pore plays an important role in ischemic postconditioning alleviating ischemia reperfusion injury.This review will discuss the mechanisms of mitochondrial permeability transition pore in ischemic postconditioning.Objective It elaborates the role of mitochondrial permeability transition pore (MPTP) in the mechanism of IPo organ protection.Content MPTP is identified as the final target of ischemic postconditioning.It is a composite protein channel located inside the mitochondrial outer membrane.Opening of MPTP is favored by intracellular calcium overload,reduced mitochondrial membrane potential,increased reactive oxygen species,release of proapoptotic proteins.IPo attenuates reperfusion injury through several signal transduction pathways,and regulation of mitochondrial permeability transition pore is an important aspect.Trend The MPTP research contributes to the exploration of the IPo organ protection mechanisms.