干细胞移植治疗失代偿期肝硬化患者110例临床评估

目的 观察干细胞移植治疗失代偿期肝硬化的疗效.方法 110例失代偿期肝硬化患者在常规治疗基础上行干细胞移植,移植后第4周复查肝功能、凝血酶原时间(PT)、胆碱酯酶(CHE)和AFP等实验室指标及观察临床症状和体征的变化.结果 移植后第4周,血浆白蛋白(ALB)和CHE分别为(31.2±4.5) g/L和(80.9±22...

Clinical analysis of stem cell transplantation on treatment of 110 patients with decompensated cirrhosis

Objective To observe the clinic effect of stem cell transplantation on treatment of patients with decompensated cirrhosis.Methods 110 patients with decompensated cirrhosis were treated by stem cell transplantation based on conventional treatment.The liver function,prothrombin time (PT),cholinesterase and alpha-fetoprotein (AFP)were detected after 4 weeks,and the changes of symptoms and signs were observed.Results Four weeks after transplantation,the levels of plasma albumin (ALB) and cholinesterase were (31.2 ± 4.5) g/L and (80.9± 22.7) U/L respectively,which were increased significantly ( t =2.95,P ＜ 0.01 ; t =2.06,P ＜ 0.05).The levels of PT was (22.9 ± 3.6)s,which decreased significantly ( t =2.18,P ＜ 0.05),but the levels of aspartate aminotransferase (ALT),alanine aminotransferase (AST),total bilirubin (TBil) and AFP had no significant changes ( t =1.32,1.58,1.05,1.57,P ＞ 0.05)before and after the transplantation.The clinical symptoms,signs and life quality of patients with decompensated cirrhosis could be significantly improved by stem cell transplantation.There were no adverse reactions and serious intraoperative complications recently.Conclusions Stem cell transplantation on treatment of patients with decompensated cirrhosis has a good short-term effect.