预注不同剂量布托啡诺对妇科腹腔镜患者术后镇痛效果的比较

目的 比较不同剂量布托啡诺静脉预注用于腹腔镜子宫切除术( laparoscopically hysterectom,LH)对患者术后镇痛作用的影响.方法 48例行全麻下择期LH患者,年龄35岁～60岁,ASA Ⅰ ～Ⅱ级,采用随机数字表法随机分为4组(每组12例),B1组、B2组、B3组分别于切皮前10 min缓注布托...

A comparison of postoperative analgesic effects with preoperative injection of the different doses of butorphanol in patients undergoing laparoscopically hysterectomy

Objective To investigate and compare postoperative analgesia effects with preoperative injection of butorphanol at different doses in patients undergoing laparoscopically hysterectomy.Methods 48 patients received general anesthesia undergoing laparoscopically hysterectomy,ASA Ⅰ -Ⅱ grade,were randomly divided into 4 groups(n=12):butorphanol 0.01,0.02,0.03 mg/kg was given slowly over 10 min before skin incision to patients in B1,B2 and B3 groups respectively; saline was injected into C (control) group.Pain and sedation were assessed using visual analogue scale(VAS) and Ramsay score at 2,4,6,12 h and 24 h after surgery.The time to regain consciousness and the adverse reactions (nausea,vomiting,dizziness,headache,respiratory depression,etc) were also recorded.All patients received the same anesthesia induction and maintenance of anesthesia.No analgesic drugs were used after surgery.Results The time to regain consciousness of B3 group (18.9±0.87) was significantly longer than that of the other three groups (6.3±0.38),(7.0±0.37),(5.5±0.03) s,P＜0.05].The VAS scores of all experimental groups were lower than C group at each postoperative time point (P＜0.05),and the VAS scores of B2 group and B3 group were lower than B2 group at each postoperative time point(P＜0.05).The Ramsay scores of all experimental groups were higher than C group after surgery,and the Ramsay scores of B3 group were significantly higher than B1 group and B2 group at 2,4,6 h after surgery.The incidence of dizziness in B3 group(41.6％) was higher than the other three groups (P＜0.05).Conclusion Preoperative intravenous injection of butorphanol 0.02 mg/kg provides better postoperative analgesia with fewer adverse reactions,which is a suitable dosage for gynaecological laparoscopy.