谷氨酸转运体与缺血性脑损伤

背景 缺血性脑损伤严重威胁人类的生命健康,谷氨酸损伤在缺血性脑损伤的疾病进展中起重要作用,调控谷氨酸浓度对缺血性脑损伤的治疗具有重要意义.目的 探讨缺血性脑损伤与谷氨酸转运体的关系及多种预处理方法对谷氨酸转运体的影响,寻找一种缺血性脑损伤的治疗方法.内容 综述谷氨酸转运体的亚型、分布、结构和功能以及谷氨酸转运体与缺血性...

Glu tamate transporters and ischemic brain injury

Background Ischemia brain injury seriously threatens human life and health.Glutamate plays a major role in the pathogenesis of ischemia brain injury,and the regulation of glutamate conce4tration on the treatment of ischemic brain injury is important.Objective To find a treatment of ischemia brain injury,we investigate the relationship between brain ischemia injury and glutamate transporters,and the effect of a variety of pretreatments on glutamate transporters.Content This review summarizes the glutamate transporter's subtype,distribution,structure and function,and the relationship with ischemic brain injury and the neuroprotective effect of pretreatments.Trend Non-ischemic pretreatment,such as electroacupuncture pretreatment and hyperbaric oxygen pretreatment of cerebral ischemia,is effective and easy to implement.Glutamate transporters would be one of the protective mechanisms.