骨髓间充质干细胞复合聚乳酸-羟基乙酸支架材料移植修复大鼠脊髓损伤后膀胱功能的实验研究

目的 研究骨髓间充质干细胞(Bone Marrow Mesenchymal Stem Cells,BMSCs)及其分化生成的神经样细胞分别复合聚乳酸-羟基乙酸(Polylactic Glycolic Acid,PLGA)支架材料移植治疗大鼠脊髓损伤的效果.方法 分别将单纯的PLGA、BMSCs-PLGA复合物以及神经样...

Bone Marrow Mesenchymal Stem Cells Combined with Polylactic Glycolic Acid Scaffold for Rat Treating Bladder Function after Spinal Cord Injury

Objectives To study separately the effect of bone marrow mesenchymal stem cells(BMSCs)and differentiated neural-like cells combined with polylactic glycolic acid(PLGA)scaffolds,both composite which restore to SD rat,s bladder function after spinal cord injury.Methods Bold scaffold,BMSCs-PLGA complex,and neural-like cells-PLGA complex were separately transplanted into SD rat models with the transection for right spinal cord,the control group which is a direct suture half crosscut spinal cord group.And obsvered SD rat models during 60 days after operation.Results BMSCs and neural-like cells can be exactly adhere to,proliferate and grow on the PLGA;BMSCs and neural-like cells combined with PLGA,which can restore to spinal cord and promote the recovery of bladder function of SD rat models.Conclusions BMSCs and differentiated neural-like cells combined with PLGA scaffolds,which can be used as a method of tissue engineering,to treat bladder function caused by spinal cord injury.