| 微小RNAs与心血管疾病 |
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| 引用本文： | 李师君. 微小RNAs与心血管疾病[J]. 国际病理科学与临床杂志, 2011, 31(6): 513-517. DOI: 10.3969/j.issn.1673-2588.2011.12.013 |
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| 作者姓名： | 李师君 |
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| 作者单位： | 中南大学湘雅二医院儿科,长沙,410011 |
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| 摘 要： | 微小RNA (miRNA)是一类内源性的单链非编码小RNA(长度约16 ～ 25个核苷酸).它们通过与靶信使RNA的3′UTR碱基互补配对,形成RNA诱导沉默复合体(RNA-induced silencing complex,RISC),抑制蛋白质的翻译或促进信使RNA分解,从而对靶基因的表达起着反向调节作用.MiRN...
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| 关 键 词： | 微小RNA 心血管系统 生长发育 疾病 |
MicroRNAs and cardiovascular disease |
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| LI Shijun. MicroRNAs and cardiovascular disease[J]. Journal of International Pathology and Clinical Medicine, 2011, 31(6): 513-517. DOI: 10.3969/j.issn.1673-2588.2011.12.013 |
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| Authors: | LI Shijun |
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| Affiliation: | LI Shijun,MAO Ding'an(Department of Pediatrics,Second Xiangya Hospital,Central South University,Changsha 410011,China) |
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| Abstract: | MiRNAs are endogenous,single-stranded and non-coding,small RNAs(about 16 to 25 nucleotides in length).RNA-induced silencing complexes(RISCs) are formed in the principle of base complementary pairing between miRNAs and the 3′UTR of targeted mRNAs.They inhibit the translation of proteins or promote the decomposition of mRNAs and in turn to regulate the expression of targeted genes negatively.miRNAs play extensive roles in the cardiovascular system.They interact with targeted mRNAs,stimulate or inhibit several signaling pathways,and thus affect the development of cardiovascular system and cardiovascular diseases.The discoveries of miRNAs have provided new explanation for disease mechanisms and thus contribute to the diagnosis or treatment for a variety of cardiovascular diseases. |
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| Keywords: | miRNA cardiovascular system development disease |
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