肾损伤分子-1、尿N-乙酰-β-D-氨基葡萄糖苷酶及尿微量白蛋白在重症感染中合并急性肾损伤的临床观察

目的 探讨尿肾损伤分子-1(Kim-1)、尿N-乙酰-β-D-氨基葡萄糖苷酶(N-acecyl-β-D-glucosaminidase,NAG)及尿微量白蛋白(mALB)在重症感染中合并急性肾损伤的敏感性及临床价值.方法 回顾分析60例在本院ICU住院的重症感染合并急性肾损伤(AKI)患者的尿Kim-1、尿NAG及尿m...

Clinical observation of kidney injury molecule-1,urine N-acetyl-beta-D-glucosaminidase and urine microalbumin in severe infection with acute kidney injury

Objectives To explore the sensitivity and clinical value of urine kidney injury molecule-1(Kim-1),urine N-acetyl-beta-D-glucosaminidase(NAG)and urine microalbumin(mALB)in patients of severe infection with acute kidney injury.Methods To retrospectively analysis the changes of urine Kim-1,urine NAG and urine mALB in 60 cases of severe infection with acute kidney injury who hospitalized in ICU.20 healthy subjects as control group.The urine Kim-1 and urine mALB were respectively determined by enzyme linked immunosorbent assay(ELISA).Urine NAG was measured by p-nitrophenol(PNP)colorimetric assay.Results Urine Kim-1,urine NAG and urine mALBwere significantly higher in AKI group,compared with control group,there were statistically significances between AKI group and control group(p ＜0.001).Through the ROC curve and diagnostic test,the results showed that,the area under the curve of urine Kim-1 was 0.756,the 95％ confidence interval was 0.910-1.000,urine Kim-1 was more sensitive than urine NAG and urine mALB(p ＜0.001),No statistically significant difference was found in age,gender proportion between AKI group and control group(p ＞ 0.05).Conclusions Urine Kim-1 had the diagnosis significance for patients of severe infection with acute kidney injury,detecting Urine Kim-1 was helpful for the early diagnosis of acute kidney injury,it had important clinical value on the prevention in pathogenesis and development of acute kidnev iniury.