| 阿莫西林合成工艺改进 |
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| 引用本文： | 郑玉林,管海英.阿莫西林合成工艺改进[J].中国抗生素杂志,2010,35(4):274. |
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| 作者姓名： | 郑玉林 管海英 |
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| 作者单位： | 上海新先锋药业有限公司产业化研究中心,上海,201203 |
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| 摘 要： | 目的 阿莫西林合成工艺的改进。方法 以6-APA为起始原料，工艺路线为6-APA胺盐溶液与混合酸酐反应得阿莫西林。结果 目标产物的结构经元素分析、IR、1H-NMR 、13C-NMR谱数据确证，且质量符合国家2005版药典。结论
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| 关 键 词： | 6-APA 阿莫西林 合成 |
Improved synthetic technology of amoxicillin |
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| Zheng Yu-lin,Guan Hai-ying.Improved synthetic technology of amoxicillin[J].Chinese Journal of Antibiotics,2010,35(4):274. |
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| Authors: | Zheng Yu-lin Guan Hai-ying |
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| Abstract: | Objective To improve the synthetic technology of amoxicillin.Methods Amoxicillin was synthesized from a main raw material 6-aminopenicillanic acid(6-APA)and acid anhydrides by nucleophilic substitution.Results The structure of final product was confirmed by elemental analysis,IR,~1H-NMR,~(13)C-NMR and the qualities of final product measure up CP2005.Conclusion Compared with original process,the problems of the reaction of mixed acid anhydrides and hydrolyzation were solved.The improved process has high yield,low cost and is easy to operate,while the quality of products is much more stable and suitable for industrial production. |
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| Keywords: | 6-APA 6-APA Amoxicillin Synthesis |
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