肝炎病毒感染者血中SOD GSH-PX LPO含量测定的意义

对５０９例门诊查体者进行了ＡＬＴ及ＨＡＶ、ＨＢＶ、ＨＣＶ、ＨＤＶ、ＨＥＶ标志物的检测；并对检测出的肝炎病毒感染者、肝炎患者以及肝炎病毒标志物阴性者（对照组）的血液进行了ＳＯＤ、ＧＳＨ－ＰＸ、ＬＰＯ测定。结果显示：肝炎病毒感染者、肝炎患者血中ＳＯＤ、ＧＳＨ－ＰＸ的含量，均显著低于对照组（Ｐ＜００５）；ＬＰＯ的含量高于对照组（Ｐ＜００５，Ｐ＜００１），当多种肝炎病毒混合感染时血ＳＯＤ、ＧＳＨ－ＰＸ下降、ＬＰＯ增高更明显，其中以ＨＢＶ、ＨＣＶ、ＨＥＶ三重叠感染及复合型肝炎（ＨＢＶ、ＨＣＶ、ＨＤＶ）时更为显著（Ｐ＜００５），提示：肝炎病毒感染者及肝炎患者血ＳＯＤ、ＧＳＨ－ＰＸ均有不同程度降低，ＬＰＯ却有不同程度增高，并与肝损伤有一定的相关性。

Changes of Blood SOD GSH-PX LPO Levels in Hepatitis Infecters and Hepatitis Patients

Aims: To investigate the changes of SOD, GSH-PX, LPO in blood of hepatitis virus infecters and hepatitis paticnts.Methods: Five kinds of hepatitis markers and ALT were measured using ELISA method in blood of 509 cases for check up, additionally, blood SOD, GSH-PX, LPO contents were assayed in 90 hepatitis virus infecters, 119 hepatitis patients and 30 cases with negative hepatitis virus markers (control group).Results: Both blood and plasma SOD, GSH-PX levels in hepatitis infecters and patients were all decreased markedly than those of normal controls ( P <0 05, P <0 01), while blood LPO levels were higher than those of normal controls ( P <0 05, P <0 01).Among them, blood SOD and GSH levels were much lower than normal controls.There existed a marked decline in HBV, HCV, HEV cross infecters and concurrent hepatitis patients (HBV, HCV, HDV) ( P <0 05, P <0 01).Conclusions: Decreased blood antioxidases level, elevated LPO level in hepatitis infecters and hepatitis patients are involved in the hepatic in jury process.