| 不同阶段铅暴露孕末期血铅水平与妊娠结局的关系 |
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| 引用本文： | 李红,马海燕,王教辰,刘秀琴,徐风森.不同阶段铅暴露孕末期血铅水平与妊娠结局的关系[J].青岛大学医学院学报,2006,42(3):234-236. |
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| 作者姓名： | 李红 马海燕 王教辰 刘秀琴 徐风森 |
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| 作者单位： | 青岛大学医学院附属青岛市市立医院儿科,山东,青岛,266011;青岛大学医学院附属青岛市市立医院病理科,山东,青岛,266011;青岛大学医学院附属青岛市市立医院妇产科,山东,青岛,266011 |
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| 基金项目： | 吴阶平医学基金会资助项目 |
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| 摘 要： | 目的 探讨孕早期、孕后期及孕全程铅暴露的毒性特点及对妊娠结局的影响。方法 用原子吸收光谱仪测定孕期不同阶段低水平铅暴露后的大鼠孕末期血铅浓度，观察记录仔鼠数、仔鼠质量和胎盘质量。结果不同阶段铅暴露孕末期血铅水平差异显著（F=12．01，P〈0．01）。孕早期铅暴露易致胎盘质量下降；孕晚期铅暴露影响仔鼠生长；全程铅暴露严重影响妊娠结局。结论 孕期不同时段铅暴露导致不同的妊娠结局，孕早期铅暴露胎盘毒性明显，孕晚期铅暴露胚胎毒性显著。
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| 关 键 词： | 铅中毒 妊娠结局 大鼠 |
| 文章编号： | 1672-4488（2006）03-0234-03 |
| 收稿时间： | 2006-02-26 |
| 修稿时间： | 2006-04-10 |
BLOOD LEAD LEVEL AND PREGNANT OUTCOME OF LEAD EXPOSURE DURING DIFFERENT GESTATION PERIODS |
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| LI HONG, MA HAI-YAN, WANG JIAO-CHEN, et al.BLOOD LEAD LEVEL AND PREGNANT OUTCOME OF LEAD EXPOSURE DURING DIFFERENT GESTATION PERIODS[J].Acta Academiae Medicinae Qingdao Universitatis,2006,42(3):234-236. |
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| Authors: | LI HONG MA HAI-YAN WANG JIAO-CHEN |
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| Abstract: | ObjectiveTo explore toxicity and pregnancy outcome of lead exposure to rats during early and late gestation periods.MethodsAtomic absorption spectrophotometer was used to detect the final phase lead concentration after different stages of lead exposure.The number of young rats,their body weight and placenta weight were measured.ResultsThe blood lead levels were significantly different among different stages.Placenta weight decreased in early period with lead exposure;growth of young rats were interfered in end period with lead exposure;the pregnancy outcome with whole period of lead exposure was influenced severely.ConclusionLead exposure in different stages of gestation results in different pregnancy outcomes: early lead exposure shows obvious toxicity in placenta,while late exposure shows striking toxicity in embryo. |
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| Keywords: | lead poisoning pregnancy outcome rats |
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