The effect of L-erythro-dihydroxyphenylserine injected into the lateral ventricle and the hypothalamus on the locomotor activity |
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| Authors: | T Noto H Hashimoto J Nakao H Kamimura T Mori T Nakajima |
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| Affiliation: | 1. Department of Networking and Communications, SRMIST, India;2. Department of Management Information Systems, College of Business Administration, Prince Sattam Bin Abdulaziz University, 165 Al-Kharj, 11942, Saudi Arabia;3. Faculty of Business & Communication, Universiti Malaysia Perlis, Jalan Kangar Alor Setar, 01000, Kangar, Perlis, Malaysia;4. Melange Academic Research Associates, Puducherry, India;5. Melange Publications, Puducherry, India;1. Department of Biomolecular Sciences, the Weizmann Institute of Science, Rehovot 7610001, Israel;2. Department of Life Sciences, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel;3. National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Be’er Sheva 84105, Israel;4. The Goldman Sonnenfeldt School of Sustainability and Climate Change, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel;1. Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, PR China;2. Tsinghua-Peking Center for Life Sciences, Beijing 100084, PR China;3. MOE Key Lab of Industrial Biocatalysts, Department of Chemical Engineering, Tsinghua University, Beijing 100084, PR China;4. Beijing PhaBuilder Biotechnology Co., LTD, Shunyi District, 101399, PR China;1. Instituto de Ingeniería, Universidad Nacional Autónoma de México, Cd. Universitaria, 04510 Coyoacán, Ciudad de Mexico, Mexico;2. Instituto de Ingeniería, Universidad Nacional Autónoma de México, Sisal, Mexico |
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| Abstract: | The effect of dihydroxyphenylserine (DOPS) on locomotor activity was studied using the Animex activity meter. One microgram of L-erythro-DOPS, a precursor of d-noradrenaline, was injected into the lateral ventricle once a day for one week or into the anterior hypothalamic area (AHA) once. After the intraventricular injection, the total locomotor activity (from 8:00 p.m. to 8:00 a.m.) of the rats injected with DOPS was significantly less than that of the rats injected with an artificial cerebrospinal fluid (5-ion). Analysis of the locomotor activity in consecutive 2-hr periods showed that the activity of the DOPS group during the time intervals of 10 p.m.-12 a.m., 12 a.m.-2 a.m. and 2 a.m.-4 a.m. was significantly less than that of the control group. After injection of DOPS or 5-ion into AHA, the total activity of the DOPS group was significantly less than that of the control. Analysis of the activity of the DOPS group for each 2-hr period between 10 p.m.-4 a.m. was also significantly less than that of the control. On the basis of these findings, the effect of DOPS in the brain noradrenergic system are discussed. |
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