| 眼前节碱烧伤后晶体超氧化物歧化酶,丙二醛含量变化与组织病理学改变 |
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| 引用本文： | 陈剑 徐锦堂. 眼前节碱烧伤后晶体超氧化物歧化酶,丙二醛含量变化与组织病理学改变[J]. 眼科研究, 1996, 14(3): 160-161 |
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| 作者姓名： | 陈剑 徐锦堂 |
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| 作者单位： | 暨南大学医学院眼科 |
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| 摘 要： | 为探索眼前节碱烧伤后晶体自由基反应与组织病理学改变关系，以新西兰兔碱烧伤为实验模型，分别测定正常眼与烧伤后不同时间晶体ＭＤＡ含量与ＳＯＤ活力，并做烧伤后晶体光学观察。结果显示，烧伤后晶体ＭＤＡ含量均显著高于正常眼，ＳＯＤ活力均显著低于正常眼。组织病理学观察，晶体上皮细胞脱落，皮质呈团块凝集、空泡样及碎片样改变。提示碱烧伤性白内障形成与自由基反应有关。
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| 关 键 词： | 化学烧伤 晶体 自由基反应 |
ChangesofActivityofSuperoxideDismutase(SOD),LevelofMalondialdehyde(MDA)andHistopathologicalObservationofLensesafterAlkaliBurn |
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| Chenjian,XuJintang,LiChenDepartmentofOphthalmology,MedicalColege,JinanUniversity,Guangzhou. ChangesofActivityofSuperoxideDismutase(SOD),LevelofMalondialdehyde(MDA)andHistopathologicalObservationofLensesafterAlkaliBurn[J]. Chinese Ophthalmic Research, 1996, 14(3): 160-161 |
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| Authors: | Chenjian XuJintang LiChenDepartmentofOphthalmology MedicalColege JinanUniversity Guangzhou |
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| Affiliation: | Chenjian,XuJintang,LiChenDepartmentofOphthalmology,MedicalColege,JinanUniversity,Guangzhou510630 |
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| Abstract: | ounderstandtherelationshipbetweenfreeredicalreactionandhistopathologyinlensesafteralkaliburn,usingtheNewZealandrabbitalkali-burnmodel,wedeterminedtheactivityofsuperoxidedismutase(SOD),levelofmalondialdehyde(MDA)inthelensesbeforeand3days,1weekand2weeksafteralkaliburns,respectively.Histopathologicalobservationofthelenseswasdone7daysafterburns.TheresultsshowedSODactivityafterburnswassignificantlylowerthanthatbeforeburns,andMDAlevelwassignifi-cantlyhigher.Severedamageinthelensesafterburnsoccuredunderlightmicroscope.Theresultssuggestedcataractafteralkaliburnsisrelatedtofreeredicalreactionoccuredinthelenese. |
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| Keywords: | chemicalburn freeredicalreaction lens |
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