| 脂联素对2型糖尿病大鼠循环CRP及sICAM-1水平的影响 |
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| 引用本文： | 刘金波,邓华聪,李丙蓉,兰丽珍,郑宏庭,诸葛福媛,吕智美. 脂联素对2型糖尿病大鼠循环CRP及sICAM-1水平的影响[J]. 中华内分泌代谢杂志, 2010, 26(3). DOI: 10.3760/cma.j.issn.1000-6699.2010.03.017 |
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| 作者姓名： | 刘金波 邓华聪 李丙蓉 兰丽珍 郑宏庭 诸葛福媛 吕智美 |
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| 作者单位： | 1. 山东大学齐鲁医院内分泌科
2. 重庆医科大学附属第一医院内分泌科,400016 |
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| 基金项目： | 国家自然科学基金，哈尔滨工业大学校科研和教改项目，教育部科学技术研究项目，教育部第二批春晖计划，重庆市教委基金渝教科 |
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| 摘 要： | 通过转染表达人全长脂联素基因的重组腺病毒载体来提高2型糖尿病大鼠血清脂联素水平.结果表明脂联素干预组血清可溶性细胞间黏附分子1(sICAM-1)和C反应蛋白(CRP)水平较糖尿病组明显下降[(18.73±4.66对23.60±4.25)mg/L和(14.91±1.79对19.09±2.95)ng/ml,均P＜0.01],提示提高循环脂联素水平可改善糖尿病炎症反应状态.
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| 关 键 词： | 脂联素 C反应蛋白 细胞间黏附分子1 糖尿病 |
Effect of adiponectin on the levels of serum CRP and sICAM-1 in type 2 diabetic rats |
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| LIU Jin-bo,DENG Hua-cong,LI Bing-rong,LAN Li-zhen,ZHENG Hong-ting,ZHUGE Fu-yuan,L Zhi-mei. Effect of adiponectin on the levels of serum CRP and sICAM-1 in type 2 diabetic rats[J]. Chinese Journal of Endocrinology and Metabolism, 2010, 26(3). DOI: 10.3760/cma.j.issn.1000-6699.2010.03.017 |
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| Authors: | LIU Jin-bo DENG Hua-cong LI Bing-rong LAN Li-zhen ZHENG Hong-ting ZHUGE Fu-yuan L Zhi-mei |
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| Affiliation: | LIU Jin-bo,DENG Hua-cong,LI Bing-rong,LAN Li-zhen,ZHENG Hong-ting,ZHUGE Fu-yuan,L(U) Zhi-mei |
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| Abstract: | Type 2 diabetic rats were treated with recombiriant adenovirus expressing human adiponectin (Ad-APN).The results showed that the levels of both plasma C-reactive protein and soluble intercellular adhesion molecule-1 were significantly decreased in Ad-APN-treated diabetic rats compared with those of diabetic rats [(18.73±4.66 vs 23.60±4.25)mg/L and (14.91±1.79 vs 19.09±2.95) ng/ml,both P＜0.01].These results suggest that increased serum concentration of adiponectin may improve the status of inflammation in diabetes mellitus. |
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| Keywords: | Adiponectin C-reactive protein Soluble intercellular adhesion molecule-1 Diabetes mellitus |
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